Abstract #1377
A longitudinal study of MR correlates during epileptogenesis in a mouse model of temporal lobe epilepsy
Niels Leonard Schwaderlapp 1 , Philipp Janz 2 , Jochen Leupold 1 , Ute Hussler 2 , Thomas Lange 1 , Dominik v. Elverfeldt 1 , Carola Haas 2 , Jrgen Hennig 1 , Laura-Adela Harsan 1 , and Pierre LeVan 1
1
Medical Physics, University Medical Center
Freiburg, Freiburg, BW, Germany,
2
Exp.
Epilepsy Research, University Medical Center Freiburg,
Freiburg, BW, Germany
Epileptogenesis involves metabolic and micro structural
alterations within subfields of the brain. Non-invasive
in-vivo monitoring of these processes provide deeper
insights and might reveal MR biomarkers for epilepsy. In
this longitudinal study, we employed 1H MR spectroscopy
and high-resolution diffusion imaging in combination
with tractography to monitor the developments during
epileptogenesis in a mouse model of temporal lobe
epilepsy. We identified early changes of relevant
metabolites (GABA, Glu, Lac, NAA, Ins) and tracked the
progression of structural changes (gliosis) in
hippocampal subfields which were validated by subsequent
in-vivo EEG recordings and immunohistochemistry.
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