Meeting Banner
Abstract #1378

MR spectroscopic studies of early post status epilepticus in rats

Yijen Lin Wu 1,2 , Patrice Pearce 1 , Amedeo Rapuano 3 , T. Kevin Hitchens 4 , Nihal deLanerolle 3 , and Jullie W Pan 1,5

1 Neurology, University of Pittsburgh, Pittsburgh, PA, United States, 2 Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 3 Neurosurgery, Yale University, New Haven, CT, United States, 4 Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, United States, 5 Radiology, University of Pittsburgh, Pittsburgh, PA, United States

The development of spontaneous recurrent seizures (epilepsy) is a complex process that commonly ensues after an initial cerebral insult. We used MR spectroscopy and T2 relaxometry in a rodent model to understand how moderate variability in status epilepticus influences such metabolic injury in early epileptogenesis. The nature of the injury can be considered to be classified as neuronal, glial or joint pathophysiological processes. The MR spectroscopic and imaging can be informative towards individual identification of injury severity and may enable identification of a MR based biomarker to predict the development of epilepsy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here