Abstract #1380
Investigating Longitudinal Metabolite and Electrophysiologic Changes Associated with Epileptogenesis in vivo in a Rat Model of Interictal Spiking Using 1 H MRS at 7 Tesla
Helen Wu 1,2 , Danielle Senador 3 , Matthew Galloway 4 , Jeffrey Loeb 5 , and Jeffrey Stanley 4
1
Wayne State University School of Medicine,
Detroit, MI, United States,
2
MD/PhD
Program, Wayne State University School of Medicine,
Detroit, MI, United States,
3
Wayne
State University School of Medicine, MI, United States,
4
Psychiatry
and Behavioral Neurosciences, Wayne State University
School of Medicine, MI, United States,
5
Neurology
and Rehabilitation Medicine, University of Illinois at
Chicago, IL, United States
We used a chronic tetanus toxin rat model of interictal
spiking as a platform to investigate longitudinal
metabolite changes associated with epileptogensis. Our
1H MRS performed in vivo at 7T provides the opportunity
to examine neocortical metabolite changes associated
with the epileptogenic process in context of concurrent
long term EEG changes. The goal of this study is to
identify key noninvasive biomarkers associated with
epileptogensis in the neocortex and characterize the
potential interplays between metabolite and
electrophysiologic changes during epilepsy development.
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