Abstract #1388
COGNITIVE RESERVE AND FUNCTIONAL CONNECTIVITY IN THE BRAIN AT REST IN RELAPSING REMITTING MUSLTIPLE SCLEROSIS
Barbara Basile 1,2 , Laura Serra 1 , Barbara Span 3 , Valeria Studer 4 , Silvia Rossi 4 , Diego Centonze 4 , Carlo Caltagirone 5 , and Marco Bozzali 1
1
Neuroimaging Laboratory, Santa Lucia
Foundation, Rome, Italy,
2
Association
of Cognitive Psychotherapy, School of Cognitive
Psychotherapy, Roma, Italy,
3
Neuroimaging
Laboratory, Santa Lucia Foundation, Roma, Italy,
4
Department
of Neuroscience, University of Rome Tor Vergata, Rome,
Italy,
5
Institute
of Neurology, Universit Cattolica, roma, Italy
"Cognitive Reserve" (CR) postulates the existence of
functional brain mechanisms that are able to cope with
cerebral damage. Cognitive functioning is impaired in
multiple sclerosis (MS), but some patients are able to
withstand considerable disease burden, without cognitive
impairment. The aim of this study was to investigate the
association between functional connectivity (FC),
measured with Resting-state-(RS)fMRI method, and levels
of CR, in patients with MS. Correlation analyses between
levels of CR and those RS-networks that are likely to be
affected in MS (i.e., Sensory-Motor and Default-Mode)
revealed specific significant associations, suggesting
the relevance of CR in modulating impairment in MS.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
