Highly reproducible whole brain myelin water mapping with FAST-T2 in 4 minutes using geometric echo time sampling

The objective was to develop fast and reproducible whole brain myelin water mapping for longitudinal study of multiple sclerosis. A 4 min Fast Acquisition with Spiral Trajectory and T2prep (FAST-T2) sequence together with a robust multi-voxel Spatially constrained Nonlinear (SPAN) data fitting algorithm enabled highly reproducible myelin water fraction measurements between repeated scans (negligible bias with 2% limits of agreement on a per voxel basis).

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