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Abstract #1387

Highly reproducible whole brain myelin water mapping with FAST-T2 in 4 minutes using geometric echo time sampling

Thanh D Nguyen 1 , Kofi Deh 1 , Sneha Pandya 1 , Elizabeth Monohan 1 , Ashish Raj 1 , Yi Wang 1 , and Susan A Gauthier 1

1 Weill Cornell Medical College, New York, NY, United States

The objective was to develop fast and reproducible whole brain myelin water mapping for longitudinal study of multiple sclerosis. A 4 min Fast Acquisition with Spiral Trajectory and T2prep (FAST-T2) sequence together with a robust multi-voxel Spatially constrained Nonlinear (SPAN) data fitting algorithm enabled highly reproducible myelin water fraction measurements between repeated scans (negligible bias with plus-or-minus sign 2% limits of agreement on a per voxel basis).

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