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Abstract #1386

Comparative Study of Quantitative MRI Markers of Disease Progression in Primary Progressive Multiple Sclerosis

Govind Nair 1 , Danish Ghazali 1 , Blake Snyder 1 , Joan Ohayon 1 , Daniel S Reich 1 , Irene Cortese 1 , and Bibiana Bielekova 1

1 NINDS, National Institutes of Health, Bethesda, MD, United States

Quantitative MRI (qMRI) markers of disease progression such as tissue volume, DTI, and quantitative T1 (qT1) from the brain and cervical spinal cord were assessed for their sensitivity to disease progression in primary progressive multiple sclerosis (PPMS). Thirty-one PPMS patients were assessed twice longitudinally using qMRI and clinical scores. Among the qMRI parameters that showed change at 1 year were qT1 from the upper cervical spinal cord, thalamic and ventricular volumes, FA from the corpus callosum, and MD from caudate. A majority of the qMRI from brain did not show any changes, probably reflecting the pathophysiology of PPMS.

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