Abstract #1386
Comparative Study of Quantitative MRI Markers of Disease Progression in Primary Progressive Multiple Sclerosis
Govind Nair 1 , Danish Ghazali 1 , Blake Snyder 1 , Joan Ohayon 1 , Daniel S Reich 1 , Irene Cortese 1 , and Bibiana Bielekova 1
1
NINDS, National Institutes of Health,
Bethesda, MD, United States
Quantitative MRI (qMRI) markers of disease progression
such as tissue volume, DTI, and quantitative T1 (qT1)
from the brain and cervical spinal cord were assessed
for their sensitivity to disease progression in primary
progressive multiple sclerosis (PPMS). Thirty-one PPMS
patients were assessed twice longitudinally using qMRI
and clinical scores. Among the qMRI parameters that
showed change at 1 year were qT1 from the upper cervical
spinal cord, thalamic and ventricular volumes, FA from
the corpus callosum, and MD from caudate. A majority of
the qMRI from brain did not show any changes, probably
reflecting the pathophysiology of PPMS.
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