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Abstract #1385

Optimizing gray-matter white-matter contrast on three-dimensional double inversion recovery MRI using patient-specific inversion times

Refaat E Gabr 1 , Xiaojun Sun 1 , Amol S Pednekar 2 , and Ponnada A Narayana 1

1 Department of Diagnostic and Interventional Imaging, The University of Texas Health Science Center at Houston, Houston, TX, United States, 2 Philips Healthcare, Cleveland, OK, United States

Optimization of double inversion recovery protocols is usually performed based on the expected relaxation times in a certain class of patients. Natural and disease-related variations in tissue relaxation cause inconsistent tissue suppression and suboptimal contrast across studies. In this work we explore a patient-specific approach for maximizing tissue contrast based on fast relaxation scout and pseudo-real-time image processing pipeline integrated into a clinical scanner. Experiments in healthy subjects show that subject-specific optimizations produce large gains in tissue contrast without scan time penalty, with only one minute of processing time.

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