Abstract #1384
Different MRI measures predict clinical deterioration and cognitive impairment in MS: a 5 year longitudinal study
Elisabetta Pagani 1 , Maria A. Rocca 1,2 , Paolo Preziosa 1,2 , Sarlota Mesaros 3 , Massimiliano Copetti 4 , Melissa Petrolini 1 , Jelena Drulovic 3 , and Massimo Filippi 1,2
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, Division of Neuroscience, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, MI, Italy,
2
Department
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, Italy,
3
Neurology
Clinic, Clinical Centre of Serbia, University of
Belgrade, Belgrade, Yugoslavia,
4
Biostatistics
Unit, IRCCS-Ospedale Casa Sollievo della Sofferenza, San
Giovanni Rotondo, Italy
The identification of imaging biomarkers for monitoring
disease progression in multiple sclerosis is an unmet
need. In this study, we assessed the value of
conventional and quantitative MRI measures of brain and
spinal cord in predicting disability and cognitive
worsening in multiple sclerosis patients after 5 years.
A random forest analysis was performed to identify
predictors of neurologic deterioration, phenotype
modification and cognitive worsening at followup. The
results showed that, while disability deterioration
seems mainly due to disruption of white matter
integrity, cognitive dysfunction is the result of a
complex interplay between white matter and grey matter
damage.
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