Meeting Banner
Abstract #1383

Moments of the T2 spectrum as a marker of resolving edema in new MS lesions

Sneha Pandya 1 , Elizabeth Monohan 2 , Michael Dayan 1 , Susan A. Gauthier 2 , and Ashish Raj 1

1 Radiology, Weill Cornell Medical College, New York, NY, United States, 2 Neurolgy, Weill Cornell Medical College, New York, NY, United States

Myelin water fraction (MWF) can be measured using multi-echo MR T2 relaxometry. MWF was shown to correspond closely with the integrity of myelin in white matter tissue, and is a sensitive marker of demyelination. However, whole brain MWF quantification in a routine clinical setting does not account for acute events accompanied by new lesions, including inflammation and edemation, and is therefore rather sensitive to those effects in addition to measuring myelin loss.We have developed a sensitive measure of these effects by computing the first and second moments of the intra/extra-cellular T2 distribution obtained from the fitted T2 spectrum.

This abstract and the presentation materials are available to members only; a login is required.

Join Here