Abstract #1383
Moments of the T2 spectrum as a marker of resolving edema in new MS lesions
Sneha Pandya 1 , Elizabeth Monohan 2 , Michael Dayan 1 , Susan A. Gauthier 2 , and Ashish Raj 1
1
Radiology, Weill Cornell Medical College,
New York, NY, United States,
2
Neurolgy,
Weill Cornell Medical College, New York, NY, United
States
Myelin water fraction (MWF) can be measured using
multi-echo MR T2 relaxometry. MWF was shown to
correspond closely with the integrity of myelin in white
matter tissue, and is a sensitive marker of
demyelination. However, whole brain MWF quantification
in a routine clinical setting does not account for acute
events accompanied by new lesions, including
inflammation and edemation, and is therefore rather
sensitive to those effects in addition to measuring
myelin loss.We have developed a sensitive measure of
these effects by computing the first and second moments
of the intra/extra-cellular T2 distribution obtained
from the fitted T2 spectrum.
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