Abstract #1390
The Influence of Surgical Correction on White Matter Microstructural Integrity in Rabbits with Familial Coronal Suture Craniosynostosis
Lesley M Foley 1 , Shinjini Kundu 2 , Wendy Fellows-Mayle 3 , T Kevin Hitchens 1,4 , Gustavo K Rohde 2 , Ramesh Grandhi 3 , Christopher M Bonfield 3 , and Mark P Mooney 5
1
Pittsburgh NMR Center for Biomedical
Research, Carnegie Mellon University, Pittsburgh, PA,
United States,
2
Department
of Biomedical Engineering, Carnegie Mellon University,
Pittsburgh, PA, United States,
3
Department
of Neurological Surgery, University of Pittsburgh,
Pittsburgh, PA, United States,
4
Department
of Biological Sciences, Carnegie Mellon University,
Pittsburgh, PA, United States,
5
Department
of Anthropology, University of Pittsburgh, Pittsburgh,
PA, United States
Craniosynostosis is where one or more of the calvarial
sutures fuse prematurely. This work examines
microstructural integrity of white matter, using DTI.
Rabbits were assigned to one of nine groups, wild type
(WT), complete fusion of the coronal suture (BC), and
surgically corrected (BC-SU) at 12, 25 or 42 days. As
age increased neurophysiological differences between WT,
BC, and BC-SU groups become more pronounced, especially
in the corpus callosum, cingulum and fimbriae. Using a
linear support vector machine classifier, classification
into WT, BC, and BC-SU groups was possible with high
accuracy. DTI revealed differences between
craniosynostotic and surgically corrected animals.
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