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Abstract #1391

Central sulcus and pericentral cortical changes in multiple sclerosis

Louise Pape 1 , Artem Mikheev 1 , Jeffrey Huang 1 , Joseph Herbert 1 , Henry Rusinek 1 , and Yulin Ge 1

1 Radiology/Center for Biomedical Imaging, NYU Langone Medical Center, New York, NY, United States

Cortical atrophy is a key imaging hallmark of multiple sclerosis (MS). The aim of this study was to investigate the differences in sulcal volume, width and depth of the central sulcus as well as pericentral cortical gray matter (Pc-CGM) thickness between MS patients and healthy controls. Results showed increased volume and width of the central sulcus and decreased Pc-CGM in patients. The sulcal changes correlated with the local atrophy measure of Pc-CGM in patients. Since CS metrics are correlated with clinical disability measure, there is potential to use them as quantitative markers of progression.

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