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Abstract #1392

Resting State Fluctuation Amplitude Indicates Impaired Cerebrovascular Reactivity in Multiple Sclerosis

Mark J. Lowe 1 , Katherine A. Koenig 1 , Xiaopeng Zhou 1 , Wanyong Shin 1 , Robert Bermel 2 , Lael Stone 2 , and Micheal D. Phillips 1

1 Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2 Neurologic Institute, Cleveland Clinic, Cleveland, OH, United States

It is known that multiple sclerosis results in decreased cerebral metabolic rate of oxygen and blood flow. Both of these are critical elements in cerebrovascular reactivity to neuronal activation. It has been shown that resting state fluctuation amplitude (RSFA) can be a surrogate to hypercapnic challenge as a measure of cerebrovascular reactivity. We show that the correlation between BOLD activation and RSFA is much weaker in MS patients than in healthy controls, indicating that cerebrovascular reactivity may be compromised in MS populations.

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