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Abstract #1393

Hippocampi and epilepsy in MS patients: a diffusion weighted imaging study with NODDI.

Alberto De Luca 1,2 , Marco Castellaro 1 , Stefania Montemezzi 3 , Massimiliano Calabrese 4 , and Alessandra Bertoldo 1

1 Department of Information Engineering, University of Padova, Padova, PD, Italy, 2 Department of Neuroimaging, Scientific Institute, IRCCS "Eugenio Medea", Bosisio Parini, LC, Italy, 3 Radiology Unit, Azienda Ospedaliera di Verona, Verona, Italy, 4 Neurology Section, Department Of Neurological and Movement Sciences, University Hospital of Verona, Verona, Italy

Multiple Sclerosis (MS) population presents higher prevalence of temporal lobe epilepsy than the healthy population. In this work we investigate if the combination of a multi-shell diffusion weighted acquisition with the NODDI model can provide insights of the differences between the hippocampi of epileptic and non-epileptic subjects in a MS population. Results show that while the fractional anisotropy index is not statistically different, the NODDI derived quantities ODI and Kappa reveal statistical differences in both the left and right hippocampi, that appear to link epileptic episodes with alterations of the fibers in these areas.

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