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Abstract #1394

Volumetric cervical spinal cord atrophy differs between younger and older onset relapsing-remitting multiple sclerosis (RRMS) and correlates with disability

Courtney A Bishop 1,2 , Emma McCarthy 3 , Richard Nicholas 2 , Lesley Honeyfield 4 , Paolo A Muraro 2,5 , Adam D Waldman 2,4 , and Rexford D Newbould 1,6

1 Imanova Centre for Imaging Sciences, London, United Kingdom, 2 Division of Brain Sciences, Imperial College London, London, United Kingdom, 3 University of Warwick, Coventry, United Kingdom, 4 Department of Imaging, Imperial College Healthcare NHS Trust, United Kingdom, 5 Department of Clinical Neurosciences, Imperial College Healthcare NHS Trust, United Kingdom, 6 Division of Experimental Medicine, Imperial College London, United Kingdom

T1-weighted volumes covering the entire cervical cord were acquired on 162 RRMS patients with an average EDSS of 3.5 and average disease duration of 4.4 years, but separated as two age groups (mean difference of 13.8 years). Semi-automated delineation of the spinal cord along the C2-C5 region revealed mean cross-sectional area (CSA) measures were significantly smaller in the older MS patients compared to the young (P=0.007) after accounting for clinical covariates, and correlated moderately well with disability (R=-0.37-0.38).

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