Relationship of resting state functional connectivity and visual acuity in MS patients with optic neuritis
Blessy Mathew 1 , Mark J. Lowe 1 , and Rob Bermel 1
Cleveland Clinic, Cleveland, OH, United
ON affects almost 50% of MS patients. It involves
inflammatory demyelination of the optic nerve leading to
partial or complete loss of vision. Recovery from ON is
variable, and a minimum of six months were required to
have passed after onset of unilateral ON for recovery to
have reached a plateau. In our study we explored the
application of fcMRI in MS patients with ON, between LGN
and V1 correlation to visual acuity. We show that visual
acuity is related to LGN-V1 functional connectivity
using fcMRI. This relationship appears to be reduced or
non-existent when visual acuity is very poor.
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