Relationship of resting state functional connectivity and visual acuity in MS patients with optic neuritis

ON affects almost 50% of MS patients. It involves inflammatory demyelination of the optic nerve leading to partial or complete loss of vision. Recovery from ON is variable, and a minimum of six months were required to have passed after onset of unilateral ON for recovery to have reached a plateau. In our study we explored the application of fcMRI in MS patients with ON, between LGN and V1 correlation to visual acuity. We show that visual acuity is related to LGN-V1 functional connectivity using fcMRI. This relationship appears to be reduced or non-existent when visual acuity is very poor.

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