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Abstract #1396

Longitudinal analysis of advanced and conventional magnetic resonance imaging measures of disease impact in multiple sclerosis

Guillaume Bonnier 1,2 , Bndicte Mortamet 1,2 , Jean-Philippe Thiran 2 , Gunnar Krueger 1,2 , Tobias Kober 1,2 , and Cristina Granziera 1

1 Siemens ACIT CHUV Radiology, Siemens Healthcare IM BM PI & Department of Radiology CHUV, Lausanne, Vaud, Switzerland, 2 LTS5, cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland

Conventional magnetic resonance imaging of patients with multiple sclerosis provides only limited insights into the nature of brain tissue damage with modest clinical-radiological correlations. In this study, we evaluated the 2 years longitudinal evolution of conventional and non-conventional markers of MS disease, in a cohort of patients with relapsing-remitting multiple sclerosis. Our cohort of patients did not show any longitudinal evolution of microstructural properties in brain normal-appearing tissue and no correlation was found between individual plaques changes and microstructural properties of brain. Our study provides evidence of the complementary nature of conventional and unconventional MRI measures for proper MS patients follow-up.

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