Abstract #1396
Longitudinal analysis of advanced and conventional magnetic resonance imaging measures of disease impact in multiple sclerosis
Guillaume Bonnier 1,2 , Bndicte Mortamet 1,2 , Jean-Philippe Thiran 2 , Gunnar Krueger 1,2 , Tobias Kober 1,2 , and Cristina Granziera 1
1
Siemens ACIT CHUV Radiology, Siemens
Healthcare IM BM PI & Department of Radiology CHUV,
Lausanne, Vaud, Switzerland,
2
LTS5,
cole Polytechnique Fdrale de Lausanne, Lausanne,
Vaud, Switzerland
Conventional magnetic resonance imaging of patients with
multiple sclerosis provides only limited insights into
the nature of brain tissue damage with modest
clinical-radiological correlations. In this study, we
evaluated the 2 years longitudinal evolution of
conventional and non-conventional markers of MS disease,
in a cohort of patients with relapsing-remitting
multiple sclerosis. Our cohort of patients did not show
any longitudinal evolution of microstructural properties
in brain normal-appearing tissue and no correlation was
found between individual plaques changes and
microstructural properties of brain. Our study provides
evidence of the complementary nature of conventional and
unconventional MRI measures for proper MS patients
follow-up.
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