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Abstract #1397

A novel Double Inversion Recovery MRI pulse sequence: improved lesion characterization for demyelinating WM and cortical lesions in Multiple Sclerosis?

Jan-Mendelt Tillema 1 , John Port 2 , Pascal Atanga 1 , Yunhong Shu 2,3 , Claudia Lucchinetti 1 , and Istvan Pirko 1

1 Neurology, Mayo Clinic, Rochester, MN, United States, 2 Radiology, Mayo Clinic, Rochester, MN, United States, 3 Biomedical Engineering and Medical Physics, Mayo Clinic, Rochester, MN, United States

In this study, a novel double inversion recovery pulse sequence was applied in patients with Multiple Sclerosis, suppressing signal from CSF and gray matter. We show a new ring pattern of signal change surrounding WM lesions that is not seen on standard DIR. Approximately 50% of the identified lesions reveal this rim pattern of hypo-intense signal change, most prominent in larger and periventricular lesions.

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