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Abstract #1398

Application of vector QSM for imaging multiple sclerosis lesions

Lijie Tu 1,2 , Cynthia Wisnieff 3 , Susan Gauthier 4 , David Pitt 5 , Yi Wang 1 , and Tian Liu 6

1 Radiology, Weill Cornell Medical College, New York, NY, United States, 2 Applied & Engineering Physics, Cornell University, Ithaca, NY, United States, 3 Tufts University, MA, United States, 4 Weill Cornell Medical College, New York, NY, United States, 5 Neurology, Yale University, New Haven, CT, United States, 6 Medimagemetric, LLC, New York, NY, United States

To image multiple sclerosis lesions in white matter, a tensor model may be needed to account for the anisotropic susceptibility effect. In this study, we applied a vector model for quantitative susceptibility mapping in human brain, which only requires a single scan. Comparison with histology confirmed that this method is able to detect spatial changes of susceptibility anisotropy. In vivo results suggest that the susceptibility observed in multiple sclerosis lesions arise primarily from iron instead of demyelination.

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