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Abstract #1399

Are outer cortical MTR changes caused predominantly by MR-visible cortical lesions or abnormalities in the normal-appearing grey matter?

Rebecca Sara Samson 1 , Manuel Jorge Cardoso 2,3 , Nils Muhlert 1 , Varun Sethi 1 , Oezguer Yaldizli 1 , Maria A Ron 1 , Sebastian Ourselin 2,3 , David H Miller 1 , Claudia A M Wheeler-Kingshott 1 , and Declan T Chard 1,4

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 2 Centre for Medical Image Computing, UCL Department of Computer Sciences, London, England, United Kingdom, 3 Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, England, United Kingdom, 4 NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom

Outer cortical magnetization transfer ratio (MTR) has the potential to be a sensitive measure of pathology linked to clinical disease progression in relapse-onset multiple sclerosis (MS). We investigated whether inner and outer cortical grey matter (GM) magnetization transfer ratio (MTR) changes are associated with MR-visible lesions, normal-appearing GM (NAGM) abnormalities, or both, in MS patients, by examining the co-localisation of cortical lesions marked on phase sensitive inversion recovery images with inner and outer cortical bands. Our findings indicate that reductions in outer cortical MTR are mostly due to changes beyond MR-visible lesions.

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