Abstract #1399
Are outer cortical MTR changes caused predominantly by MR-visible cortical lesions or abnormalities in the normal-appearing grey matter?
Rebecca Sara Samson 1 , Manuel Jorge Cardoso 2,3 , Nils Muhlert 1 , Varun Sethi 1 , Oezguer Yaldizli 1 , Maria A Ron 1 , Sebastian Ourselin 2,3 , David H Miller 1 , Claudia A M Wheeler-Kingshott 1 , and Declan T Chard 1,4
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, England, United Kingdom,
2
Centre
for Medical Image Computing, UCL Department of Computer
Sciences, London, England, United Kingdom,
3
Dementia
Research Centre, Department of Neurodegenerative
Diseases, UCL Institute of Neurology, London, England,
United Kingdom,
4
NIHR
University College London Hospitals Biomedical Research
Centre, London, United Kingdom
Outer cortical magnetization transfer ratio (MTR) has
the potential to be a sensitive measure of pathology
linked to clinical disease progression in relapse-onset
multiple sclerosis (MS). We investigated whether inner
and outer cortical grey matter (GM) magnetization
transfer ratio (MTR) changes are associated with
MR-visible lesions, normal-appearing GM (NAGM)
abnormalities, or both, in MS patients, by examining the
co-localisation of cortical lesions marked on phase
sensitive inversion recovery images with inner and outer
cortical bands. Our findings indicate that reductions in
outer cortical MTR are mostly due to changes beyond
MR-visible lesions.
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