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Abstract #1400

Detection of demyelination and remyelination in multiple sclerosis by analysis of T2* relaxation at 7T

Xiaozhen Li 1,2 , Peter van Gelderen 1 , Pascal Sati 3 , Jacco de Zwart 1 , Daniel Reich 3 , and Jeff Duyn 1

1 Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, Maryland, United States, 2 Dept. NVS, Karolinska Institutet, Huddinge, Stockholm, Sweden, 3 Translational Neuroradiology Unit, DNN, NINDS, National Institutes of Health, Bethesda, Maryland, United States

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by the formation of focal demyelinated (plaques, or lesions). To detect this ongoing demyelination in MS patient brains in newly forming (Gadolinium-enhancing) lesions, we studied changes in T2* relaxation over serial scans covering a 6-month time span. Use of a three-component model-fit to the data allowed us to monitor changes in myelin water (and thus indirectly myelin content), axonal water and interstitial water. Our results showed the changes for R2* (1/T2*) of axonal water at different lesion evolution stages, which may help further understand the disease evolution in MS.

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