Detection of demyelination and remyelination in multiple sclerosis by analysis of T2* relaxation at 7T
Xiaozhen Li 1,2 , Peter van Gelderen 1 , Pascal Sati 3 , Jacco de Zwart 1 , Daniel Reich 3 , and Jeff Duyn 1
Advanced MRI Section, LFMI, NINDS, National
Institutes of Health, Bethesda, Maryland, United States,
NVS, Karolinska Institutet, Huddinge, Stockholm, Sweden,
Neuroradiology Unit, DNN, NINDS, National Institutes of
Health, Bethesda, Maryland, United States
Multiple sclerosis (MS) is a chronic demyelinating
disease of the central nervous system characterized by
the formation of focal demyelinated (plaques, or
lesions). To detect this ongoing demyelination in MS
patient brains in newly forming (Gadolinium-enhancing)
lesions, we studied changes in T2* relaxation over
serial scans covering a 6-month time span. Use of a
three-component model-fit to the data allowed us to
monitor changes in myelin water (and thus indirectly
myelin content), axonal water and interstitial water.
Our results showed the changes for R2* (1/T2*) of axonal
water at different lesion evolution stages, which may
help further understand the disease evolution in MS.
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