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Abstract #1405

Quantitative Susceptibility Mapping (QSM) indicates disturbed brain iron homeostasis in Neuromyelitis Optica

Thomas Martin Doring 1 , Vanessa Granado 2 , Gustavo Tukamoto 3 , Fernanda Rueda 3 , Andreas Deistung 4 , Juergen Reichenbach 5 , Emerson Gasparetto 6 , and Ferdinand Schweser 7

1 Radiodiagnostic Imaging, DASA, Rio de janeiro, Rio de Janeiro, Brazil, 2 Radiologia, CDPI, Rio de Janeiro, Brazil, 3 CDPI, Rio de Janeiro, Brazil, 4 Medical Physics, Uni Jena, Thueringen, Germany, 5 Medical Physics Group, Uni Jena, Thueringen, Germany, 6 DASA, Rio de Janeiro, Brazil, 7 CTRC and Buffalo Neuroimaging Analysis Center, University of NY, Buffalo NY, United States

Neuromyelitis optica (NMO) is a severe, inflammatory demyelinating disease that typically affects optic nerve and spinal cord. The purpose of the current study was to investigate brain iron and myelin in NMO patients using two quantitative imaging techniques, R2* mapping and the relatively new Quantitative Susceptibility Mapping. Advanced neuroimaging techniques have recently been explored to discover new diagnostic criteria to detect NMO and to overcome the problem to distinguish this disease from MS.

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