Neurite orientation dispersion and density Imaging (NODDI) in Multiple Sclerosis
Sourajit Mitra Mustafi 1 , Chandana Kodiweera 2 , Jennifer S Randolph 3 , James C Ford 3 , Heather A Wishart 3 , and Yu-chien Wu 1
Center for Neuroimaging, Indiana Univeristy,
Indianapolis, Indiana, United States,
College, NH, United States,
Medical School, Lebanon, NH, United States
Conventional MR imaging, including T1-weighted
(pre-/post- contrast), T2-weighted, and T2-weighted
fluid-attenuated inversion recovery scans, are used in
the diagnosis and monitoring of MS but leave the
underlying micromechanisms of tissue damage unclear.
Diffusion MRI measures water diffusion behaviors in
biological systems, and is sensitive to microstructural
white matter (WM) changes in MS. In this study, we used
neurite orientation dispersion and density imaging
(NODDI) to study the brain in humans with MS. NODDI
hypothesizes WM microstructures in three compartments:
extracellular, intracellular and cerebrospinal fluid
compartment. NODDI information may help explain the
microstructural changes in MS at cellular level.
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