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Abstract #1404

Neurite orientation dispersion and density Imaging (NODDI) in Multiple Sclerosis

Sourajit Mitra Mustafi 1 , Chandana Kodiweera 2 , Jennifer S Randolph 3 , James C Ford 3 , Heather A Wishart 3 , and Yu-chien Wu 1

1 Center for Neuroimaging, Indiana Univeristy, Indianapolis, Indiana, United States, 2 Dartmouth College, NH, United States, 3 Dartmouth Medical School, Lebanon, NH, United States

Conventional MR imaging, including T1-weighted (pre-/post- contrast), T2-weighted, and T2-weighted fluid-attenuated inversion recovery scans, are used in the diagnosis and monitoring of MS but leave the underlying micromechanisms of tissue damage unclear. Diffusion MRI measures water diffusion behaviors in biological systems, and is sensitive to microstructural white matter (WM) changes in MS. In this study, we used neurite orientation dispersion and density imaging (NODDI) to study the brain in humans with MS. NODDI hypothesizes WM microstructures in three compartments: extracellular, intracellular and cerebrospinal fluid compartment. NODDI information may help explain the microstructural changes in MS at cellular level.

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