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Abstract #1403

Detecting Iron Deposition In Multiple Sclerosis Using Susceptibility Contrast Imaging

Bing Yao 1,2 , Sarah Wood 1,3 , Zhiguo Jiang 4 , Glenn Wylie 1,2 , and John DeLuca 1,2

1 Rocco Ortenzio Neuroimaging Center, Kessler Foundation, West Orange, NJ, United States, 2 Department of Physical Medicine & Rehabilitation, Rutgers University, Newark, NJ, United States, 3 Psychology Department, Montclair State University, Montclair, NJ, United States, 4 Human Performance Engineering Lab, Kessler Foundation, West Orange, NJ, United States

Hypointensity of deep brain gray matter structures in T2*-weighted images (T2WI) of multiple sclerosis (MS) patients has been reported and suggested to represent increased iron deposition. However, these findings are difficult to generalize as the contrast in T2WI depends on several MR parameters including TE, TR, and others. Here, we explored using quantitative susceptibility contrast imaging including R2* and quantitative susceptibility map to identify characteristic regions suggestive of increased iron deposition in MS patients.

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