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Abstract #1411

Multimodal Imaging of Functional Alterations of the Thalamus Following Mild Traumatic Brain Injury

Chandler Sours 1,2 , Elijah George 1,2 , Steven Roys 1,2 , Jiachen Zhuo 1,2 , and Rao P Gullapalli 1,2

1 Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2 Magnetic Resonance Research Center, Baltimore, MD, United States

The aim of this study is to investigate the acute functional alterations in the thalamus following mild traumatic brain injury (mTBI) using resting state fMRI (rs-fMRI) and magnetic resonance spectroscopy imaging (MRSI). Results suggest that in addition to reduced NAA/Cr in the thalamus, acute mTBI patients have increased thalamo-cortical connectivity, including both cortical areas associated with primary sensory processing and cortical areas associated with the Default Mode Network. These results provide evidence for a functionally damaged thalamus in the initial days following mTBI and may be associated with common post concussive symptoms experienced by these patients.

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