Abstract #1418
Comparison of DTI group analysis using non-linear and linear registration techniques
Blessy Mathew 1 , Wanyong Shin 1 , Mingyi Li 1 , Mark J. Lowe 1 , Sarah Banks 2 , Michael Phillips 1 , Michael T. Modic 1 , and Charles Bernick 2
1
Cleveland Clinic, Cleveland, OH, United
States,
2
Cleveland
Clinic, Las Vegas, Nevada, United States
From the longitudinal professional fighter's brain
health study of active professional fighters, ROI based
DTI result has been published to show the fight history
or number of knock outs (NKO) predicts DTI changes in 74
of boxers and 81 mixed martial arts fighters (MMA). In
this study, we ran voxel-wise DTI group analysis to
replicate the previous finding from ROI analysis and to
expand predefined ROIs to whole brain using linear and
nonlinear registration methods. We conclude that, in a
large cohort of subjects at risk for brain trauma, the
non-linear technique is better at detecting group-level
structural changes than the linear technique.
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