Parametric response map (PRM) is a promising tool for the monitoring of post traumatic cerebral edema

Post-traumatic cerebral edema in preclinical trials is usually assessed using the Apparent diffusion coefficient (ADC) measured by diffusion-weighted magnetic resonance imaging. One generally estimates ADC as the average value inside specific regions of interest (ROI). Parametric response map (PRM), a voxel-based analysis, is a tool to investigate spatially dispersed changes of ADC over time. It allows to detect edematous processes that are not necessarily detected by the mean ADC value approach. PRM gives some spatial and chronologic details that could distinguish different sub population based on their ADC evolution. This technique is promising in the field of traumatic brain injury.

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