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Abstract #1416

Evidence for abnormal venous drainage in a closed head model of pediatric mild traumatic brain injury using 9.4T MRI

Elizabeth Imhof 1 , Michael Esser 1,2 , Carolyn JoAnne MacMillan 1 , Richelle Mychasiuk 1,2 , and Jeffrey F. Dunn 1,2

1 University of Calgary, Calgary, Alberta, Canada, 2 Alberta Childrens Hospital Research Institute, Calgary, Alberta, Canada

Mild traumatic brain injury and concussion are becoming increasingly recognised as a growing health problem, making it important to understand the pathophysiology and MRI metrics that correlate with injury. We studied a mild, closed head model of pediatric concussion using 9.4T MRI. Rats were imaged 24h post-injury with perfusion, T2, and T2* and anatomical scans. There was no change in quantitative metrics, confirming this is a model of mild injury. The key finding was enlargement of venous sinuses. This provides evidence for abnormal venous calibre in mTBI which highlights the needs to understand venous involvement in mTBI.

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