Abstract #1416
Evidence for abnormal venous drainage in a closed head model of pediatric mild traumatic brain injury using 9.4T MRI
Elizabeth Imhof 1 , Michael Esser 1,2 , Carolyn JoAnne MacMillan 1 , Richelle Mychasiuk 1,2 , and Jeffrey F. Dunn 1,2
1
University of Calgary, Calgary, Alberta,
Canada,
2
Alberta
Childrens Hospital Research Institute, Calgary,
Alberta, Canada
Mild traumatic brain injury and concussion are becoming
increasingly recognised as a growing health problem,
making it important to understand the pathophysiology
and MRI metrics that correlate with injury. We studied a
mild, closed head model of pediatric concussion using
9.4T MRI. Rats were imaged 24h post-injury with
perfusion, T2, and T2* and anatomical scans. There was
no change in quantitative metrics, confirming this is a
model of mild injury. The key finding was enlargement of
venous sinuses. This provides evidence for abnormal
venous calibre in mTBI which highlights the needs to
understand venous involvement in mTBI.
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