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Abstract #1420

Connectome-scale Assessment of Structural and Functional Connectivity in Mild Traumatic Brain Injury at the Acute Stage

Armin Iraji 1 , Hanbo Chen 2 , Natalie Wiseman 1 , Tuo Zhang 2 , Robert Welch 1 , Brian O'Neil 1 , Andrew Kulek 1 , Syed Imran Ayaz 1 , Xiao Wang 1 , Conor Zuk 1 , E. Mark Haacke 1 , Tianming Liu 2 , and Zhifeng Kou 1

1 Wayne State University, Detroit, Michigan, United States, 2 University of Georgia, Georgia, United States

Mild traumatic brain injury is a public healthcare burden that costs the nation billions of dollars each year. Numerous data using diffusion tensor imaging have reported widely spread damage in major white matter tracts, in suggestion of large-scale network disruptions or alternations. However, very limited data investigated the scale and extent of brain network changes after mTBI. We used a novel approach to identifying the large-scale brain network alternations in both structure and function in mTBI patients at the acute stage. This work represents the first effort to investigate the scale and extent of brain network changes after mTBI.

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