Resting-State Functional Magnetic Resonance Imaging Connectivity and Behavioral Outcomes in Traumatic Brain Injury
Shiliang Huang 1 , Qiang Shen 1 , Lora Talley Watts 1 , Justin Alexander Long 1 , Wei Li 1 , and Timothy Q Duong 1
Research Imaging Institute, The University
of Texas Health Science Center at San Antonio, San
Antonio, TX, United States
Resting state functional MRI studies have reported
disrupted functional connectivity after traumatic brain
injury (TBI) in humans. The types, time after injury,
extent and location of TBI in humans are heterogeneous.
Animal models of TBI offer a means to study the effects
of injury on rsfMRI under controlled conditions. The
goal of this study was to use independent component
analysis (ICA) method to investigate longitudinal
changes of functional connectivity in moderate traumatic
brain injury in rats. Comparisons were made with
functional outcomes measured by forelimb placement
asymmetry and foot fault behavioral tests.
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