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Abstract #1422

Brain Injury and Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (BIMA): Auditory Functional Magnetic Resonance Imaging at Baseline

Priya Santhanam 1 , Peter Cartwright 2 , Thomas G Perkins 3,4 , Terrence R Oakes 1 , John Graner 1 , Gerard P Riedy 1,5 , Lindell K Weaver 6,7 , and William W Orrison 2,8

1 National Intrepid Center of Excellence (NICoE), Bethesda, MD, United States, 2 Imgen, LLC, Las Vegas, NV, United States, 3 Philips Healthcare, Cleveland, OH, United States, 4 Perkins Consultative Resources LLC, Fort Collins, CO, United States, 5 Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States, 6 Department of Hyperbaric Medicine, Intermountain LDS Hospital and Intermountain Medical Center, Salt Lake City, UT, United States, 7 School of Medicine, University of Utah, Salt Lake City, UT, United States, 8 Department of Health Physics, University of Nevada Las Vegas, Las Vegas, NV, United States

This study seeks to examine alterations in brain activity during an auditory task in patients with mild traumatic brain injury (mTBI). Study participants completed a word-listening task that was presented unilaterally in each ear as well as bilaterally. Comparison of three evaluation methods (clinical radiological read, clinical computer analysis, and full GLM analysis) was performed. Radiological score and clinical computer analysis yielded a high degree of concordance, and furthermore, clinical computer analysis and GLM analysis had significant correlations. This study demonstrates the reliability and reproducibility of the task for evaluation of auditory deficits in an mTBI population.

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