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Abstract #1431

Suppression of streak artifacts in quantitative susceptibility mapping

Wen-Tung Wang 1 , Dzung Pham 1 , and John A Butman 1,2

1 Center for Neuroscience and Regenerative Medicine, Bethesda, MD, United States, 2 Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States

Quantitative Susceptibility Mapping (QSM) offers unique, quantitative information about the magnetic susceptibility of tissues. While multi-orientation QSM can faithfully reconstruct susceptibility maps, it is computationally demanding and impractical for clinical scans. Single-orientation QSMs mitigate computational load and patient discomfort, but streak artifacts in susceptibility maps may still appear due to mathematical approximations. We propose to apply the single-orientation QSM twice, one at chin-up and the other chin-down orientation, using fast 3D segmented EPI to reduce streak artifacts while maintaining accuracy of the susceptibility measurements. The average of the two orientations substantially eliminates the artifacts as compared to a single orientation.

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