Abstract #1432
Recovery of consciousness in brain injury: insights from the structural and functional connectome
Amy Kuceyeski 1 , Sudhin Shah 2 , Jonathan Dyke 3 , Stephen Bickel 4 , Farras Abdelnour 3 , Nicholas Schiff 5 , Henning Voss 5 , and Ashish Raj 5
1
Radiology and Brain and Mind Research
Institute, Weill Cornell Medical College, New York, NY,
United States,
2
Neurology,
Weill Cornell Medical College, NY, United States,
3
Radiology,
Weill Cornell Medical College, NY, United States,
4
Neurology,
Albert Einstein College of Medicine, NY, United States,
5
Weill
Cornell Medical College, NY, United States
Subjects with severe brain injury suffer widespread
deafferentation and connectivity loss across brain
regions, at times resulting in disorders of
consciousness. We test if parameters from a mathematical
model of linear network diffusion predicting functional
networks from structural networks (extracted from MRI)
relate to level of consciousness in 26 severe brain
injury patients. A strong Pearsons correlation was
found between level of consciousness and the model
parameter describing the amount of time the predicted
functional connectivity was allowed to diffuse along the
structural connectivity network (r=0.79, p=0.0016).
These findings invite further consideration of
underlying biological mechanisms in recovery of
consciousness.
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