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Abstract #1432

Recovery of consciousness in brain injury: insights from the structural and functional connectome

Amy Kuceyeski 1 , Sudhin Shah 2 , Jonathan Dyke 3 , Stephen Bickel 4 , Farras Abdelnour 3 , Nicholas Schiff 5 , Henning Voss 5 , and Ashish Raj 5

1 Radiology and Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States, 2 Neurology, Weill Cornell Medical College, NY, United States, 3 Radiology, Weill Cornell Medical College, NY, United States, 4 Neurology, Albert Einstein College of Medicine, NY, United States, 5 Weill Cornell Medical College, NY, United States

Subjects with severe brain injury suffer widespread deafferentation and connectivity loss across brain regions, at times resulting in disorders of consciousness. We test if parameters from a mathematical model of linear network diffusion predicting functional networks from structural networks (extracted from MRI) relate to level of consciousness in 26 severe brain injury patients. A strong Pearsons correlation was found between level of consciousness and the model parameter describing the amount of time the predicted functional connectivity was allowed to diffuse along the structural connectivity network (r=0.79, p=0.0016). These findings invite further consideration of underlying biological mechanisms in recovery of consciousness.

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