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Abstract #1434

Non-invasive measurement of cerebral arterial compliance during post exercise ischemia

Esther Warnert 1 , Emma Hart 2 , Kevin Murphy 1 , Adele Babic 3 , Judith Hall 3 , and Richard Wise 1

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2 BHI Cardionomics Research Group, Bristol University, Bristol, United Kingdom, 3 Department of Anaesthetics and Intensive Care Medicine, Cardiff University, Cardiff, United Kingdom

It is still unclear whether the decrease in cerebrovascular compliance under stress occurs at the level of the major brain feeding arteries or of the cerebral arterioles because of the difficulty of in vivo measurement of cerebral arterial compliance in humans. In this experiment we use our novel MRI based method to measure cerebral arterial compliance to investigate the differential response of the cerebrovasculature to post exercise ischemia (PEI), which elevates blood pressure and sympathetic nerve activity. We found a decrease in compliance of the major brain feeding arteries, while compliance of arterioles distal to the Circle of Willis remained unchanged, during PEI compared to rest.

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