Abstract #1434
Non-invasive measurement of cerebral arterial compliance during post exercise ischemia
Esther Warnert 1 , Emma Hart 2 , Kevin Murphy 1 , Adele Babic 3 , Judith Hall 3 , and Richard Wise 1
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, United Kingdom,
2
BHI
Cardionomics Research Group, Bristol University,
Bristol, United Kingdom,
3
Department
of Anaesthetics and Intensive Care Medicine, Cardiff
University, Cardiff, United Kingdom
It is still unclear whether the decrease in
cerebrovascular compliance under stress occurs at the
level of the major brain feeding arteries or of the
cerebral arterioles because of the difficulty of in vivo
measurement of cerebral arterial compliance in humans.
In this experiment we use our novel MRI based method to
measure cerebral arterial compliance to investigate the
differential response of the cerebrovasculature to post
exercise ischemia (PEI), which elevates blood pressure
and sympathetic nerve activity. We found a decrease in
compliance of the major brain feeding arteries, while
compliance of arterioles distal to the Circle of Willis
remained unchanged, during PEI compared to rest.
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