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Abstract #1435

Test-retest reproducibility of BOLD-CVR measures in children using a computer-controlled CO 2 challenge

Jackie Leung 1 , Junseok Kim 2 , and Andrea Kassner 1,3

1 The Hospital for Sick Children, Toronto, Ontario, Canada, 2 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, 3 Medical Imaging, University of Toronto, Toronto, Ontario, Canada

Cerebrovascular reactivity (CVR) is a form of a cerebrovascular 'stress test' that offers insight into the function of cerebrovasculature and has shown applicability in the clinical assessment cerebrovascular disease. Good reproducibility has previously been shown in adults using blood-oxygen level-dependent (BOLD) MRI measures in combination with a model-free prospective end-tidal targeting (MPET) system. However, reproducibility in children using this method has not yet been established. Our study shows good within-day and between-day reproducibility of BOLD-CVR measures using the MPET that is comparable to the adult data.

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