Abstract #1436
Characterization of Vascular Response in White Matter to Hypercapnia and Hyperoxia
Binu P Thomas 1 , Virendra Mishra 1 , Shin-Lei Peng 1 , Hao Huang 1 , and Hanzhang Lu 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States
WM dysfunction is typically imaged using structural MRI
techniques such as DTI, magnetization transfer and
T2weighted-MRI. Unfortunately, these techniques do not
provide physiological information. The goal of this
study is to perform a thorough examination of WM
vascular physiology. WM was classified into 10 major
fibers, and layers with increasing depth from the
cortical surface, and their vascular response to O2 and
CO2 was measured. Results suggest that with increase in
depth in the WM, blood supply and reactivity of blood
vessels decreases. Data also suggest that fiber tracts
have their own blood supply and that reactivity of these
blood vessels is different.
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