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Abstract #1436

Characterization of Vascular Response in White Matter to Hypercapnia and Hyperoxia

Binu P Thomas 1 , Virendra Mishra 1 , Shin-Lei Peng 1 , Hao Huang 1 , and Hanzhang Lu 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States

WM dysfunction is typically imaged using structural MRI techniques such as DTI, magnetization transfer and T2weighted-MRI. Unfortunately, these techniques do not provide physiological information. The goal of this study is to perform a thorough examination of WM vascular physiology. WM was classified into 10 major fibers, and layers with increasing depth from the cortical surface, and their vascular response to O2 and CO2 was measured. Results suggest that with increase in depth in the WM, blood supply and reactivity of blood vessels decreases. Data also suggest that fiber tracts have their own blood supply and that reactivity of these blood vessels is different.

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