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Abstract #1437

Comparing Cerebrovascular Reactivity Measured using BOLD and Cerebral Blood Flow at Various Vascular Tension Levels

Sheliza Halani 1 , Jonathan B Kwinta 2 , Ali M Golestani 2 , Yasha B Khatamian 2 , and J. Jean Chen 1,3

1 Rotman Research Institute, Baycrest, Toronto, Ontario, Canada, 2 Rotman Research Institute, Baycrest, Ontario, Canada, 3 Medical Biophysics, University of Toronto, Ontario, Canada

In this work, we use simultaneous BOLD-CBF acquisitions with vasodilatory (hypercapnic) and vasoconstrictive (hypocapnic) stimuli to measure CVR, and imposed different levels of baseline vascular tension. We saw significant and diverse dependencies on vascular stimulus and baseline condition in both BOLD and CBF CVR measurements: (i) BOLD-based CVR is more sensitive to vascular tension than CBF- CVR; (ii) using a combination of vasodilatory and vasoconstrictive stimuli reduces the vascular-tension dependence of both BOLD- and CBF-CVR. As vascular tension can often be altered by potential pathology, our findings are important considerations when interpreting CVR measurements in health and disease.

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