Abstract #1437
Comparing Cerebrovascular Reactivity Measured using BOLD and Cerebral Blood Flow at Various Vascular Tension Levels
Sheliza Halani 1 , Jonathan B Kwinta 2 , Ali M Golestani 2 , Yasha B Khatamian 2 , and J. Jean Chen 1,3
1
Rotman Research Institute, Baycrest,
Toronto, Ontario, Canada,
2
Rotman
Research Institute, Baycrest, Ontario, Canada,
3
Medical
Biophysics, University of Toronto, Ontario, Canada
In this work, we use simultaneous BOLD-CBF acquisitions
with vasodilatory (hypercapnic) and vasoconstrictive
(hypocapnic) stimuli to measure CVR, and imposed
different levels of baseline vascular tension. We saw
significant and diverse dependencies on vascular
stimulus and baseline condition in both BOLD and CBF CVR
measurements: (i) BOLD-based CVR is more sensitive to
vascular tension than CBF- CVR; (ii) using a combination
of vasodilatory and vasoconstrictive stimuli reduces the
vascular-tension dependence of both BOLD- and CBF-CVR.
As vascular tension can often be altered by potential
pathology, our findings are important considerations
when interpreting CVR measurements in health and
disease.
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