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Abstract #1438

Investigating the effect of cardiorespiratory fitness on cerebrovascular reactivity using breath-hold fMRI

Hannah Furby 1 , Molly G Bright 1 , Esther AH Warnert 1 , Chris J Marley 2 , Damian M Bailey 2 , and Richard G Wise 1

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2 Neurovascular Research Laboratory, University of South Wales, Pontypridd, United Kingdom

Cerebrovascular reactivity (CVR) is a potential biomarker of neurovascular health and tool for measuring the therapeutic effects of physical exercise on the brain. FMRI methods have not been used to investigate whether physical fitness can predict CVR in healthy young adults. Using PASL, hemodynamic changes in response to breath-holds were combined as a measure of CVR in young adults of varying physical fitness. CVR decreased, albeit non-significantly, in those who were physically fitter. However, BOLD and CBF measurements were significantly correlated across fitness levels, suggesting that CBF and BOLD MRI are useful tools for measuring CVR.

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