Abstract #1438
Investigating the effect of cardiorespiratory fitness on cerebrovascular reactivity using breath-hold fMRI
Hannah Furby 1 , Molly G Bright 1 , Esther AH Warnert 1 , Chris J Marley 2 , Damian M Bailey 2 , and Richard G Wise 1
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, United Kingdom,
2
Neurovascular
Research Laboratory, University of South Wales,
Pontypridd, United Kingdom
Cerebrovascular reactivity (CVR) is a potential
biomarker of neurovascular health and tool for measuring
the therapeutic effects of physical exercise on the
brain. FMRI methods have not been used to investigate
whether physical fitness can predict CVR in healthy
young adults. Using PASL, hemodynamic changes in
response to breath-holds were combined as a measure of
CVR in young adults of varying physical fitness. CVR
decreased, albeit non-significantly, in those who were
physically fitter. However, BOLD and CBF measurements
were significantly correlated across fitness levels,
suggesting that CBF and BOLD MRI are useful tools for
measuring CVR.
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