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Abstract #1439

T2, Diffusion, and Perfusion Abnormalities are associated with Impaired Cerebrovascular Reactivity in the Normal-appearing White Matter of Elderly Subjects with Leukoaraiosis.

Kevin Sam 1,2 , Boris Peltenburg 2 , Adrian P. Crawley 2 , Julien Poublanc 2 , Olivia Sobczyk 2 , Diem Pham 3 , David E. Crane 3 , Christopher J.M. Scott 3 , Alicia A. McNeely 3 , Daniel M. Mandell 2 , Joseph A. Fisher 1 , Sandra E. Black 3 , and David J. Mikulis 2

1 Department of Physiology, University of Toronto, Toronto, Ontario, Canada, 2 Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario, Canada, 3 Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada

Cerebrovascular reactivity in the normal-appearing white matter was assessed by using the BOLD MRI signal in response to a consistently applied step change in the arterial partial pressure of carbon dioxide. We examined quatitative T2, diffusion, and perfusion maps in the white matter and found subtle abnormalities in these metrics that were associated with impaired cerebrovascular reactivity.

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