Abstract #1440
Evaluation of respiratory fluctuation in cerebral venous blood oxygenation for diagnosis of arteriolar function
Keigo Nishi 1 , Minghui Tang 1 , and Toru Yamamoto 2
1
Graduate school of health Sciences, Hokkaido
university, Sapporo, Hokkaido, Japan,
2
Faculty
of Health Sciences, Hokkaido university, Sapporo,
Hokkaido, Japan
Venous blood oxygenation in the resting-state fluctuates
because of neuronal activity and arteriolar vasomotion
driven by respiratory PaCO2 changes. These fluctuations
of venous blood oxygenation at respiratory range reflect
arteriolar function. Deterioration of arteriolar
function can be used to diagnose dementia an early
stage. To obtain information of arteriolar function, MR
signals fluctuation from the sagittal sinus was
measured. However, the turbulence in the sinus prevents
the proper measurement of the fluctuation of blood
oxygenation. We developed a method to achieve precise
measurement by using blood velocity mapping, and
evaluated respiratory fluctuation of blood oxygenation.
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