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Abstract #1440

Evaluation of respiratory fluctuation in cerebral venous blood oxygenation for diagnosis of arteriolar function

Keigo Nishi 1 , Minghui Tang 1 , and Toru Yamamoto 2

1 Graduate school of health Sciences, Hokkaido university, Sapporo, Hokkaido, Japan, 2 Faculty of Health Sciences, Hokkaido university, Sapporo, Hokkaido, Japan

Venous blood oxygenation in the resting-state fluctuates because of neuronal activity and arteriolar vasomotion driven by respiratory PaCO2 changes. These fluctuations of venous blood oxygenation at respiratory range reflect arteriolar function. Deterioration of arteriolar function can be used to diagnose dementia an early stage. To obtain information of arteriolar function, MR signals fluctuation from the sagittal sinus was measured. However, the turbulence in the sinus prevents the proper measurement of the fluctuation of blood oxygenation. We developed a method to achieve precise measurement by using blood velocity mapping, and evaluated respiratory fluctuation of blood oxygenation.

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