Abstract #1442
Mapping Human Cerebral Vascular/Metabolic Activity Coupling at High-Resolution
William D. Rooney 1,2 , Xin Li 1 , Dennis N. Bourdette 3 , and Charles S. Springer, Jr. 1,2
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Knight
Cardiovascular Institute, Oregon Health & Science
University, Portland, Oregon, United States,
3
Department
of Neurology, Oregon Health & Science University,
Portland, Oregon, United States
The unidirectional rate constant for
equilibrium
capillary
water efflux, k
po
, has been mapped with high
resolution in the normal and normal-appearing MS human
brain. It is the reciprocal of the mean capillary water
molecule lifetime. The rate constant k
po
is
greater in white matter than in gray matter. Comparison
with literature spectroscopic imaging of metabolites and
metabolic fluxes shows that k
po
tracks
the oxidative phosphorylation flux per capillary. The k
po
quantity
detects whole-brain compromise in early stage MS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
