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Abstract #1445

Quantification of perfusion and xenon-transport across the blood-brain barrier in humans with hyperpolarized 129 Xe brain MR at 1.5T

Madhwesha Rao 1 , Neil Stewart 1 , Graham Norquay 1 , and Jim Wild 1

1 University of Sheffield, Sheffield, South Yorkshire, United Kingdom

When inhaled into the lungs, xenon dissolves in blood, and is carried to the brain via the systemic circulation, where it, crosses the blood-brain barrier and dissolves into brain tissue. 129Xe has large chemical shift providing contrast for cerebral blood, grey-matter, white-matter and lipid. In this work, using hyperpolarized xenon we measure the transfer rate of xenon from cerebral blood to brain tissue across the blood-brain barrier. The transit response of the blood-brain barrier is demonstrated and proposed as a physiological indication of intrinsic permeability to xenon.

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