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Abstract #1446

The impact of fluctuated tCBF induced by cardiac pulsation on the global CMRO2 measurement

Chou-Ming Cheng 1,2 , Hsiao-Wen Chung 2 , Jen-Chuen Hsieh 1,3 , Shing-Jong Lin 1 , and Tzu-Chen Yeh 3,4

1 Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan, 2 Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taiwan, Taiwan, 3 Institute of Brain Science, National Yang-Ming University, Taiwan, Taiwan, 4 Department of Radiology, Taipei Veterans General Hospital, Taiwan, Taiwan

Recently, the total cerebral blood flow (tCBF) and venous oxygen saturation (SvO2) levels are measured noninvasively with the MRI approaches to quantify the global cerebral metabolic rate of oxygen (CMRO2). In this research, the ROI analysis with the cardiac gating sequence is applied in healthy subjects to demonstrate the impact of fluctuated tCBF induced by cardiac pulsation on the global CMRO2 measurement.

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