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Abstract #1447

Comparative Analyses of Magnetic Field Correlation Imaging, Quantitative Susceptibility Mapping and Transverse Relaxation Rate R2* Indices of Brain Iron in Healthy Adults

Vitria Adisetiyo 1 , Jens H. Jensen 1 , Chu-Yu Lee 1 , Donna R. Roberts 1 , Maria V. Spampinato 1 , and Joseph A. Helpern 1,2

1 Radiology and Radiological Science, Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States, 2 Neuroscience, Medical University of South Carolina, Charleston, SC, United States

The disruption of brain iron homeostasis has been implicated in many neuropathologies. Investigation of such iron-related neuropathologies may, therefore, benefit from in vivo brain iron MRI methods. Although relaxation rates R2, R2* and R2' are commonly used to measure brain iron, their limitations have been well documented. In this study, we directly compare R2* with magnetic field correlation imaging and quantitative susceptibility mapping in healthy adult brains and correlate these metrics with previously reported putative postmortem iron concentrations (CPM). All metrics significantly correlate to CPM when all brain regions are assessed together but within regions, the metrics show differential correlations.

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