Abstract #1447
Comparative Analyses of Magnetic Field Correlation Imaging, Quantitative Susceptibility Mapping and Transverse Relaxation Rate R2* Indices of Brain Iron in Healthy Adults
Vitria Adisetiyo 1 , Jens H. Jensen 1 , Chu-Yu Lee 1 , Donna R. Roberts 1 , Maria V. Spampinato 1 , and Joseph A. Helpern 1,2
1
Radiology and Radiological Science, Center
for Biomedical Imaging, Medical University of South
Carolina, Charleston, SC, United States,
2
Neuroscience,
Medical University of South Carolina, Charleston, SC,
United States
The disruption of brain iron homeostasis has been
implicated in many neuropathologies. Investigation of
such iron-related neuropathologies may, therefore,
benefit from in vivo brain iron MRI methods. Although
relaxation rates R2, R2* and R2' are commonly used to
measure brain iron, their limitations have been well
documented. In this study, we directly compare R2* with
magnetic field correlation imaging and quantitative
susceptibility mapping in healthy adult brains and
correlate these metrics with previously reported
putative postmortem iron concentrations (CPM). All
metrics significantly correlate to CPM when all brain
regions are assessed together but within regions, the
metrics show differential correlations.
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