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Abstract #1448

Time Course and Distribution of Feraheme in the Normal Human Brain at 7T

Michael Zeineh 1 , Samantha Holdsworth 1 , Michael Moseley 1 , and Brian Rutt 1

1 Radiology, Stanford University, Stanford, California, United States

Feraheme is an intravenous ultra-small iron oxide particle potentially useful for studying neuroinflammation with MRI. Ultra-high field MRI should be exquisitely sensitive to Feraheme. However, the distribution and timecourse of Feraheme has not been explored at ultra-high field. In this study, we examined the uptake and washout of Feraheme in a single volunteer at 7T. Low signal was identified Day 1 after injection in the occipital and parietal lobes, presumbably from Feraheme within small blood vessels. This low signal only partially resolved by Day 4. The remainder of the brain demonstrated minimal if any low signal in the cortex.

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