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Abstract #1449

The relative contributions of the transition metals iron and manganese to T 1 and T 2 in white and gray matter

Kimberly L. Desmond 1,2 , Alia Al-Ebraheem 1 , Rafal Janik 2,3 , Wendy Oakden 2,4 , Jacek M. Kwiecien 5 , Wojciech Dabrowski 6 , Kalotina Geraki 7 , Greg J. Stanisz 2,4 , Michael Farquharson 1 , and Nicholas A. Bock 1

1 Medical Physics and Radiation Sciences, McMaster University, Hamilton, Ontario, Canada, 2 Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada, 3 Medical Biophysics, University of Toronto, Ontario, Canada, 4 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, 5 Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada, 6 Anaesthesiology and Intensive Therapy, Lublin Medical University, Lublin, Poland, 7 Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom

In vivo , quantitative, T 1 and T 2 MRI maps in gray and white matter of the severely myelin-deficient Shaker rat and age-matched controls were combined with metal maps of iron and manganese obtained with synchrotron radiation X-Ray fluorescence (XRF). Given the relaxivities of the transition metals and their concentrations from XRF, it was found that a substantial proportion of 1/T 1 was due to the transition metals, and a much lesser proportion of 1/T 2 . These results suggest that T 1 and T 2 could be combined to disentangle the effects of myelin, Fe and Mn in demyelinating diseases with suspected transition metal involvement.

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