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Abstract #1450

Assessing Reproducibility and Changes in Oxygenation with R2 during Clinical Hypercapnic and Hypoxic Gas Challenges

Wendy W Ni 1,2 , Thomas Christen 2 , and Greg Zaharchuk 2

1 Department of Electrical Engineering, Stanford University, Stanford, California, United States, 2 Department of Radiology, Stanford University, Stanford, California, United States

R2-based oxygenation mapping with gas challenges is a promising area of research in clinical neuroimaging. Currently, there are few published studies on reproducibility, which is a crucial factor for clinical applicability. In this study, we rigorously evaluated reproducibility and changes of two R2 measurements in normal young subjects, using a multi-echo modified GESFIDE sequence during hypercapnia and hypoxia, with extensive concurrent physiological monitoring. We observed statistically significant reduction in R2 during hypercapnia and slight increase during hypoxia, providing a strong platform for further MR-based studies in quantification and validation of regional brain tissue oxygenation.

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