Abstract #1450
Assessing Reproducibility and Changes in Oxygenation with R2 during Clinical Hypercapnic and Hypoxic Gas Challenges
Wendy W Ni 1,2 , Thomas Christen 2 , and Greg Zaharchuk 2
1
Department of Electrical Engineering,
Stanford University, Stanford, California, United
States,
2
Department
of Radiology, Stanford University, Stanford, California,
United States
R2-based oxygenation mapping with gas challenges is a
promising area of research in clinical neuroimaging.
Currently, there are few published studies on
reproducibility, which is a crucial factor for clinical
applicability. In this study, we rigorously evaluated
reproducibility and changes of two R2 measurements in
normal young subjects, using a multi-echo modified
GESFIDE sequence during hypercapnia and hypoxia, with
extensive concurrent physiological monitoring. We
observed statistically significant reduction in R2
during hypercapnia and slight increase during hypoxia,
providing a strong platform for further MR-based studies
in quantification and validation of regional brain
tissue oxygenation.
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