Abstract #1451
Quantitative T 1 Mapping and Oxygen Enhanced MRI in Patients with Interstitial Lung Disease
Kerry Hart 1,2 , Helen Marshall 1 , Neil Stewart 1 , Martin Deppe 1 , Steve Bianchi 3 , Rob Ireland 2 , Moira Whyte 4 , David Kiely 3 , and Jim Wild 1
1
Academic Unit of Radiology, University of
Sheffield, Sheffield, United Kingdom,
2
Academic
Unit of Clinical Oncology, University of Sheffield,
Sheffield, United Kingdom,
3
Pulmonary
Vascular Disease Unit, Royal Hallamshire Hospital,
Sheffield, United Kingdom,
4
Academic
Unit of Respiratory Medicine, University of Sheffield,
Sheffield, United Kingdom
In patients with interstitial lung disease the
interstitium becomes thickened, resulting in less
efficient gas exchange. Quantitative T
1
mapping
was performed under normal and hyperoxic conditions in
patients with idiopathic pulmonary fibrosis (IPF),
patients with systemic sclerosis (SSc) and healthy
volunteers. Data showed significantly reduced baseline
lung T
1
values
in IPF and SSc compared to healthy subjects. The
magnitude of oxygen induced T
1
shortening
in IPF was shown to be significantly smaller than in
healthy subjects. Baseline lung T
1
and
the magnitude of T
1
shortening
in response to oxygen inhalation were shown to correlate
with the alveolar septal thickness measured with
129
Xe
MRI and the diffusing capacity of the lung for carbon
monoxide (DLCO).
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