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Abstract #1451

Quantitative T 1 Mapping and Oxygen Enhanced MRI in Patients with Interstitial Lung Disease

Kerry Hart 1,2 , Helen Marshall 1 , Neil Stewart 1 , Martin Deppe 1 , Steve Bianchi 3 , Rob Ireland 2 , Moira Whyte 4 , David Kiely 3 , and Jim Wild 1

1 Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2 Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom, 3 Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom, 4 Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield, United Kingdom

In patients with interstitial lung disease the interstitium becomes thickened, resulting in less efficient gas exchange. Quantitative T 1 mapping was performed under normal and hyperoxic conditions in patients with idiopathic pulmonary fibrosis (IPF), patients with systemic sclerosis (SSc) and healthy volunteers. Data showed significantly reduced baseline lung T 1 values in IPF and SSc compared to healthy subjects. The magnitude of oxygen induced T 1 shortening in IPF was shown to be significantly smaller than in healthy subjects. Baseline lung T 1 and the magnitude of T 1 shortening in response to oxygen inhalation were shown to correlate with the alveolar septal thickness measured with 129 Xe MRI and the diffusing capacity of the lung for carbon monoxide (DLCO).

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