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Abstract #1453

Longitudinal MRI of Progressive Pulmonary Fibrosis in a Transgenic, TGF-Alpha-Induced Mouse Model

Zackary I. Cleveland 1 , R. Scott Dunn 2 , Cynthia R. Davidson 3 , Jinbang Guo 1,4 , Jason C Woods 1,4 , and William D. Hardie 3

1 Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2 Imaging Research Center, Department of Radiology, Cincinnati Childrens Hospital Medical Center, OH, United States, 3 Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, OH, United States, 4 4) Department of Physics, Washington University, St. Louis, MO, United States

Idiopathic pulmonary fibrosis (IPF) is a poorly understood, progressive, and fatal disease. Although, mouse models are vital to IPF research, they typically provide little temporal and spatial insight, and most models fail to exhibit the non-inflammatory, progressive fibrosis seen in clinical IPF. We report the first imaging study of a non-inflammatory, progressive, transgenic mouse model that mimics key biological and temporal aspects of human IPF. In addition to noninvasively visualizing the expected pattern of fibrotic progression, this study revealed previously unknown, dynamic tissue remodeling; demonstrating that longitudinal MRI applied to relevant, preclinical models can provide novel insights into IPF biology.

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