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Abstract #1459

Detection of Chronic Allograft Dysfunction using Ventilation-Weighted Fourier Decomposition Lung MRI

Andreas Voskrebenzev 1,2 , Lena Becker 1,2 , Marcel Gutberlet 1,2 , Christian Schnfeld 1,2 , Julius Renne 1,2 , Jan Hinrichs 1,2 , Till Kaireit 1,2 , Tobias Welte 2,3 , Frank Wacker 1,2 , Jens Gottlieb 2,3 , and Jens Vogel-Claussen 1,2

1 Institute of Diagnostic and Interventional Radiology, Medical School Hanover, Hanover, Germany, 2 German Centre for Lung Research, Hanover, Germany, 3 Department of Pneumology, Medical School Hanover, Hanover, Germany

Survival after lung transplantation is limited by bronchiolitis obliterans syndrome (BOS). A cross-sectional study with 66 patients after double lung transplantation and 12 healthy controls was conducted to assess if ventilation-weighted Fourier Decomposition (FD)-MRI can differentiate between BOS stages. For this purpose quartile coefficient of dispersion (QCD) was calculated for each subject. The QCD increased according to the stage of disease and the Mann-Whitney U-test showed significant differences between volunteers and BOS 0 as well as between BOS 0 and BOS 1-3 patients. In conclusion, FD lung MRI is a promising tool to detect graft dysfunction due to BOS.

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