Abstract #1459
Detection of Chronic Allograft Dysfunction using Ventilation-Weighted Fourier Decomposition Lung MRI
Andreas Voskrebenzev 1,2 , Lena Becker 1,2 , Marcel Gutberlet 1,2 , Christian Schnfeld 1,2 , Julius Renne 1,2 , Jan Hinrichs 1,2 , Till Kaireit 1,2 , Tobias Welte 2,3 , Frank Wacker 1,2 , Jens Gottlieb 2,3 , and Jens Vogel-Claussen 1,2
1
Institute of Diagnostic and Interventional
Radiology, Medical School Hanover, Hanover, Germany,
2
German
Centre for Lung Research, Hanover, Germany,
3
Department
of Pneumology, Medical School Hanover, Hanover, Germany
Survival after lung transplantation is limited by
bronchiolitis obliterans syndrome (BOS). A
cross-sectional study with 66 patients after double lung
transplantation and 12 healthy controls was conducted to
assess if ventilation-weighted Fourier Decomposition
(FD)-MRI can differentiate between BOS stages. For this
purpose quartile coefficient of dispersion (QCD) was
calculated for each subject. The QCD increased according
to the stage of disease and the Mann-Whitney U-test
showed significant differences between volunteers and
BOS 0 as well as between BOS 0 and BOS 1-3 patients. In
conclusion, FD lung MRI is a promising tool to detect
graft dysfunction due to BOS.
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