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Abstract #1462

Lung imaging at ultra-high magnetic fields in rodents

Marta Tibiletti 1 , Detlef Stiller 2 , Volker Rasche 1 , and Andrea Bianchi 2

1 Core Facility Small Animal MRI, Ulm University, Ulm, Baden-Wrttemberg, Germany, 2 Target Discovery Research, In-vivo imaging laboratory, Boehringer Ingelheim Pharma GmbH & Co. KG, Baden-Wrttemberg, Germany

In this work, we demonstrate the feasibility of pre-clinical lung imaging at ultra-high magnetic fields (11.7 T) using 3D ultra-short echo time (UTE) and zero echo-time (ZTE) imaging. The results obtained at 11.7 T resulted similar with the one acquired at 7 T in comparable conditions. T2* relaxation time of lung at these magnetic fields were also calculated with a sequence of 3D UTE. ZTE images demonstrated lower SNR than UTE images, but also to be more robust to motion artifacts.

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